Pharmacy - Graduate Pharmacy Aptitude Test (GPAT)

Drug Delivery, Mechanism of Action & Natural Products question bank (Pharmaceutics, Pharmacology & Pharmacognosy)

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Q1.

Pharmaceutics (Suspensions): According to Stokes' Law in 'Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability', the rate of settling (sedimentation velocity $v$) of suspended pharmaceutical particles is inversely proportional to:

(A)

Viscosity of the dispersion medium ($\eta$) (Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability)

(B)

Square of the particle radius ($r^2$)

(C)

Difference in densities between particle and liquid ($\rho_p - \rho_f$)

(D)

Acceleration due to gravity ($g$)

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Q2.

Pharmacokinetics (Elimination): A drug follows first-order elimination kinetics with an elimination rate constant $k_e = 0.0693\text{ hour}^{-1}$ in 'Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability'. What is the biological half-life ($t_{1/2}$)?

(A)

10 hours ($t_{1/2} = \frac{0.693}{k_e} = \frac{0.693}{0.0693} = 10\text{ hours}$) (Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability)

(B)

5 hours

(C)

20 hours

(D)

14 hours

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