Pharmacy - Graduate Pharmacy Aptitude Test (GPAT)

Drug Delivery, Mechanism of Action & Natural Products question bank (Pharmaceutics, Pharmacology & Pharmacognosy)

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Q1.

Pharmacognosy: Which therapeutically vital indole alkaloid extracted from the dried roots of Rauwolfia serpentina acts as an antihypertensive agent by depleting vesicular catecholamines in 'Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability'?

(A)

Reserpine (Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability)

(B)

Quinine

(C)

Atropine

(D)

Vincristine

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Q2.

Pharmaceutical Analysis (Chromatography): In thin-layer chromatography (TLC) in 'Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability', what does the Retention Factor ($R_f$) represent?

(A)

Ratio of the distance traveled by the solute to the distance traveled by the solvent front (Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability)

(B)

Time taken by the mobile phase to traverse the column

(C)

Volume of stationary phase retained on silica gel

(D)

Peak area normalized to internal standard

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